Program runs in "Compatibility Troubleshooter" but not from desktop

Program developed in VS2010 was downloaded to a system running Windows 7 professional. The program started and ran for an hour before the system was shut down. Later the system was powered up again but the program would not launch from Startup, its desktop icon, or its folder. Ran the "Compatibility Troubleshooter" and the program started from there. Accepted the settings and went back to the folder but the program would not launch. Re-installed the program with same results. Why does it run from inside the troubleshooter b ut not the folder?